What substances are typically included in a DOT drug test panel?

The substances typically included in a DOT drug test panel are marijuana, cocaine, opiates, amphetamines, and phencyclidine (PCP). This panel is designed to detect the most commonly abused drugs that may impair an individual's ability to perform safety-sensitive functions in the transportation industry.

The inclusion of these specific substances is guided by federal regulations, as they represent some of the most prevalent and significant risks when it comes to workplace safety. For instance, marijuana and cocaine are well-known recreational drugs that can severely impair judgment and coordination. Opiates and amphetamines also have the potential to impact cognitive and physical performance, making their monitoring critical in ensuring safe transportation operations. PCP is included due to its strong dissociative effects, which can dramatically affect a person's functioning and safety on the job.

The other options include substances that are not part of the standard DOT drug test panel, such as alcohol, nicotine, LSD, heroin, ecstasy, and meth. While some of these substances can influence performance, the DOT guidelines specifically focus on the first five substances in the correct answer.